149 research outputs found

    Методичні вказівки до виконання дипломних проектів та робіт для здобуття освітньо-кваліфікаційного рівня «бакалавр» за напрямом підготовки 6.050701 Електротехніка та електротехнології та рівня «спеціаліст» за спеціальністю «Електротехнічні системи електроспоживання»

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    Методичні вказівки містять вимоги до кваліфікаційних робіт, проблематику, за якою визначаються теми, рекомендації з оформлення їх складових та з організації захисту. Орієнтовані на студентів та керівників кваліфікаційних робіт для організації і виконання завдань навчального плану підготовки бакалаврів та спеціалістів

    О плазменно-вибрационном воздействии на железорудный массив в условиях термического котлообразования

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    Розглянуті процеси об’ємної іонізації в кварцитах, які виникають при плазмово-віброударній дії на мінерали. Показано, що плазмово віброударне навантаження матеріалів приводить до виникнення локальних областей з аномальним ефектом Шоттки.The process of volume ionization in the quartzite, that arose at plasma-vibrostriking action upon minerals, was considered. It was shown, that the plasma-vibrostriking loading of materials resulted in the appearance of local regions with an anomalous Shottci effect

    Применение систем бесперебойного электропитания в экстренной медицине

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    Рассмотрены особенности построения систем бесперебойного электропитания экстренных медицинских отделений на базе преобразователей напряжения. Представлены функциональные схемы систем бесперебойного электропитания, а также осциллограммы переходных процессов выходного напряжения при работе системы на комплекс параллельно соединенных разнородных нагрузок

    Molecular analysis of microcin 24 : Genetics, secretion and mode of action of a novel microcin

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    Colicins and microcins are proteinaceous antimicrobial agents produced by members of the Enterobacteriaceae which are active against other members of this family. Colicin24 is a novel bacteriocin produced by a uropathogenic strain of Escherichia coli isolated at Christchurch Hospital. Through detailed genetic analysis of the DNA encoding this toxin and assaying the toxic activity, colicin 24 was re-classified as microcin 24 and has been shown to have a similar genetic organisation to that of colicin V and a novel mode of activity. The region of DNA encoding microcin 24 was subcloned from pGOB34 into pBR322 generating pGOB18 (5.44kb). Mutagenesis, DNA sequencing and transcomplementation identified two regions with high sequence similarity and functional homology to the ColV transporters CvaA and CvaB. The insert DNA of pGOB18 was sequenced in both directions and has been found to contain 5267bp encoding five open reading frames, mdbA, mtft, mtfS, mtfA and mtfB, forming three operons mdbA, mtfI/mtfS and mtfA/mtfB all of which were transcribed in the same direction. The predicted protein products of all the open reading frames except mtfB were confirmed by expressing the genes in minicells. Further mutagenesis and trans-complementation has identified mdbA as a cis acting positive regulatory gene with sequence similarity to the histone-like proteins. The mtfI and mtfS genes were confirmed as the Mcc24 immunity gene and the Mcc24 structural gene respectively. The genes mtfA and mtfB were found to encode the transport proteins homologous to CvaA and CvaB respectively, with mtfB encoding a protein which is a member of the ABC family of bacterial transporters. Transport also requires the TolC outer membrane protein. Analysis of the mtfS DNA sequence has identified a double glycine leader sequence, making MtfS the second microcin after ColV to belong to this class of peptide antibiotics. Experimental evidence suggested that unlike ColV, Mcc24 is inactive within the producing cell, however both toxins require the ABC transporter for post-translational modification of the pre-peptide. The regulation of Mcc24 synthesis is controlled by the interaction between σs, Fur, and MdbA, encoded by the mdbA gene. Analysis of the promoter sequences has identified putative regions of DNA bending which might facilitate the binding of σs and MdbA. A Fur-box with good sequence similarity to the consensus Fur-box has been identified in the mtfI/mtfS promoter and is the proposed site for Fur binding. The activity spectrum of Mcc24 is restricted to enteric bacteria and SernA, the MccE492 receptor, is also required as the receptor for Mcc24. Extracts of Mcc24 have been found to degrade both linearised and covalently closed circular DNA in vitro. The activity is absent in extracts from mtfS - strains, suggesting that Mcc24 inhibits the growth of sensitive cells by degrading DNA. The effect of Mcc24 expression on the virulence of E. coli was tested using the embryo lethality assay, however unlike ColV which increases the virulence of strains, the expression of Mcc24 did not appear to have a significant effect on E. coli virulence in this system

    Проект установки отмывки электролитического порошка титана от фторидных солей электролита производительностью 30 кг/час

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    Выпускная квалификационная работа в форме дипломного проекта 118 с., 24 рис., 23 табл., 46 источников, 1 приложение. Ключевые слова: электролиз, катодный осадок, отмывка. Цель работы – спроектировать цех для проведения процесса отмывки титанового порошка. Основные конструктивные, технологические и технико-эксплуатационные характеристики: Объем и габаритные размеры основного аппарата составляют: V = 0,25 м3, D = 0,8 м, H = 1,8 м. Степень внедрения: проект находится на стадии разработки. Область применения: Химическая технология редких металлов. Экономическая эффективность/значимость работы: экономический эффект – снижение себестоимости титанового порошка и увеличение прибыли.Die Abschlußqualifikationsarbeit in Form vom Diplomprojekt 118 mit., 24 Abb., 23 Tabellen, 46 Quellen, 1 Anlage. Die Stichwörter: die Elektrolyse, die Kathodenablagerung, das Abwaschen. Das Ziel der Arbeit – die Abteilung für die Verwirklichung des Prozesses des Abwaschens des Titanpulvers zu entwerfen. Die Haupt- konstruktiven, technologischen und techniko-Betriebscharakteristiken: der Umfang und die Ladeumfänge des Hauptapparates bilden: V = 0,25 м3, D = 0,8 m, H = 1,8 m Die Stufe der Einführung: das Projekt befindet sich auf dem Stadium der Entwicklung. Das Gebiet der Anwendung: die Chemische Technologie der seltenen Metalle. Die Wirtschaftseffektivität/Bedeutsamkeit der Arbeit: der Nutzeffekt – die Selbstkostenverringerung des Titanpulvers und die Vergrößerung des Gewinnes

    Artistic Content Representation and Modelling based on Visual Style Features

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    This thesis aims to understand visual style in the context of computer science, using traditionally intangible artistic properties to enhance existing content manipulation algorithms and develop new content creation methods. The developed algorithms can be used to apply extracted properties to other drawings automatically; transfer a selected style; categorise images based upon perceived style; build 3D models using style features from concept artwork; and other style-based actions that change our perception of an object without changing our ability to recognise it. The research in this thesis aims to provide the style manipulation abilities that are missing from modern digital art creation pipelines

    Hey koca dünya

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    Sürur Bedi'nin Son Saat'te tefrika edilen Hey Koca Dünya adlı roman

    Mev’ud hüküm

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    Halide Edip'in Yeni Mecmua'da yayımlanan Mev'ud Hüküm adlı romanının ilk ve son tefrikalarıTelif hakları nedeniyle romanın tam metni verilememiştir

    Global economic burden of unmet surgical need for appendicitis

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    Background: There is a substantial gap in provision of adequate surgical care in many low-and middle-income countries. This study aimed to identify the economic burden of unmet surgical need for the common condition of appendicitis. Methods: Data on the incidence of appendicitis from 170 countries and two different approaches were used to estimate numbers of patients who do not receive surgery: as a fixed proportion of the total unmet surgical need per country (approach 1); and based on country income status (approach 2). Indirect costs with current levels of access and local quality, and those if quality were at the standards of high-income countries, were estimated. A human capital approach was applied, focusing on the economic burden resulting from premature death and absenteeism. Results: Excess mortality was 4185 per 100 000 cases of appendicitis using approach 1 and 3448 per 100 000 using approach 2. The economic burden of continuing current levels of access and local quality was US 92492millionusingapproach1and92 492 million using approach 1 and 73 141 million using approach 2. The economic burden of not providing surgical care to the standards of high-income countries was 95004millionusingapproach1and95 004 million using approach 1 and 75 666 million using approach 2. The largest share of these costs resulted from premature death (97.7 per cent) and lack of access (97.0 per cent) in contrast to lack of quality. Conclusion: For a comparatively non-complex emergency condition such as appendicitis, increasing access to care should be prioritized. Although improving quality of care should not be neglected, increasing provision of care at current standards could reduce societal costs substantially
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